
	Pakistan Journal of Biological Sciences
	Year: 2012 \| Volume: 15 \| Issue: 2 \| Page No.: 98-102 DOI: 10.3923/pjbs.2012.98.102

The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial

N. Namazi, A. Tarighat and A. Bahrami

Abstract: Diabetes type 2 is a metabolic disorder that characterized by hyperglycemia and insulin resistance. Hyperglycemia and impairment of oxidant/antioxidant balance, can increase oxidative stress and increase risk of cardiovascular disease. In the present study, Effects of hydro alcoholic extract of Nettle on oxidative stress in type 2 diabetes were evaluated. Fifty patients (27 men, 23 women) with type 2 diabetes patients were studied. They received 100 mg kg^-1 of nettle extract of body weight hydro alcoholic for 8 weeks. At the baseline and end of 8th weeks of intervention blood levels of oxidative stress markers were measured. Data was analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, Total Antioxidant Capacity (TAC) and Superoxidant Dismutase (SOD) showed a significant increase in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has increasing effects on TAC and SOD in patients with type 2 diabetes without no changes in Malondialdehyde (MDA) and Glutathione Peroxides (GPX) after eight weeks intervention.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial

•	Oxidative Stress in the Liver of Diabetic Rats Treated with a Combination of Sildenafil Citrate and a Free Radical Scavenger

•	Evaluation of Phenolic Content and Antioxidant Property of Hydrolysed Extracts of Terminalia catappa L. Leaf

•	Protective Effects of Green tea (Camelia sinensis), Hypericum perforatum and Urtica dioica on Hepatic Injury and Lymphocyte DNA Damage Induced by Carbon Tetrachloride in Wistar Rats

•	The Protective Activity of Urtica dioica Leaves on Blood Glucose Concentration and β-cells in Streptozotocin-Diabetic Rats

•	Comparative Study of the Status of a Biomarker of Lipid Peroxidation (Malondialdehyde) in Patients with Plasmodium falciparum and Plasmodium vivax Malaria Infection

How to cite this article:

N. Namazi, A. Tarighat and A. Bahrami, 2012. The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial. Pakistan Journal of Biological Sciences, 15: 98-102.

DOI: 10.3923/pjbs.2012.98.102

URL: https://scialert.net/abstract/?doi=pjbs.2012.98.102

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI

Science Alert