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Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 6 | Page No.: 375-384
DOI: 10.3923/pjbs.2011.375.384
 
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Idiotype/Anti-idiotype Immunoregulatory Network Correlates with an Improved Clinical Outcome of Schistosomiasis mansoni in Humans

Sherif H. Abdeen

Abstract:
Anti-idiotypes (anti-Ids) have a potential role in the immune modulation of various diseases. To study the correlation of anti-Ids with schistosomiasis mansoni morbidity, ELISA using polyclonal idiotypes (Ids) was used to determine the presence of anti-Ids in sera of 69 patients susceptible and resistant to re-infection. Ids were purified against Soluble Worm Antigen (SWAP) from sera of New Zealand white rabbits immunized with SWAP. The results showed that anti-Ids were detected in 15 (40.5%) of susceptible and 21 (65.6%) of resistant patients. Correlation of intensity of infection with age revealed an inverse relationship in patients positive for anti-Ids (regression coefficient β = - 0.47, p<0.05) and contrarily, a direct relationship in patients negative for anti-Ids (β = 0.67, p<0.001). In addition, there was a direct association between the presence of anti-Ids and the lack of schistosome-related symptoms (χ2 = 3.6, p<0.05) and hepatomegaly (χ2 = 9.4, p<0.01). Moreover, comparison of patients positive and negative for anti-Ids revealed that those negative for anti-Ids were more vulnerable to develop symptoms (3.7 times) and hepatomegaly (8.1 times). In conclusion, the study further confirms the role of Id/anti-Id regulatory network as an important participant in the assortment of an improved clinical outcome of schistosomiasis. This may help to formulate a better understanding of the mechanisms of protective immunity in humans and provide perspective for the development of a future vaccine.
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How to cite this article:

Sherif H. Abdeen , 2011. Idiotype/Anti-idiotype Immunoregulatory Network Correlates with an Improved Clinical Outcome of Schistosomiasis mansoni in Humans. Pakistan Journal of Biological Sciences, 14: 375-384.

DOI: 10.3923/pjbs.2011.375.384

URL: https://scialert.net/abstract/?doi=pjbs.2011.375.384

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