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Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 22 | Page No.: 1019-1023
DOI: 10.3923/pjbs.2011.1019.1023
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Screening of Endophytic Fungi Having Ability for Antioxidative and α-Glucosidase Inhibitor Activities Isolated from Taxus sumatrana

N. Artanti, S. Tachibana, L.B.S. Kardono and H. Sukiman

Endophytic microbes are considered as an important source of natural products. They show antibiotic, anticancer, antioxidative and antidiabetic activities. Therefore, there are many reports on the isolation and bioactivity screening of endophytic fungi from various plants including Taxus species. Taxus sumatrana (Miq.) de Laub is found in Indonesia. The objective of this study is to conduct an in vitro screening of 14 endophytic fungi isolated from Taxus sumatrana having antioxidative and α-glucosidase inhibitor activities. Each endophytic fungus was cultured for 7 days and the fungal mycelium and medium were extracted with methanol and ethyl acetate, respectively, to produce each extract. The antioxidative activity of each extract was tested by DPPH free radical scavenging activity and β-carotene bleaching assays, whereas antidiabetic activity was tested based on α-glucosidase inhibitor activity. The screening results showed that fungal mycelia of TSC 13 had the best α-glucosidase inhibitor activity and TSC 24 had the best antioxidative activity. Isolation of bioactive compounds from TSC 13 and TSC 24 is being conducted. This is the first report that endophytic fungi isolated from T. sumatrana exhibited anti α-glucosidase inhibitory and anti oxidative activities.
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  •    Anti-diabetic Activity of Endophytic Fungi, Penicillium Species of Tabebuia argentea; in Silico and Experimental Analysis
  •    Effect of Media Compositions on α-glucosidase Inhibitory Activity, Growth and Fatty Acid Content in Mycelium Extracts of Colletotrichum sp. TSC13 from Taxus Sumatrana (Miq.) de Laub
  •    Isolation, Characterization and α-glucosidase Inhibitory Activity of Crude Beta Glucan from Silver Ear Mushroom (Tremella fuciformis)
  •    Isolation of α-glucosidase Inhibitors Produced by an Endophytic Fungus, Colletotrichum sp. TSC13 from Taxus sumatrana
  •    Inhibitory Effect of Koji Aspergillus terreus on α-Glucosidase Activity and Postprandial Hyperglycemia
  •    In vitro Antioxidative Activities and Polyphenol Content of Eugenia polyantha Wight Grown in Indonesia
How to cite this article:

N. Artanti, S. Tachibana, L.B.S. Kardono and H. Sukiman, 2011. Screening of Endophytic Fungi Having Ability for Antioxidative and α-Glucosidase Inhibitor Activities Isolated from Taxus sumatrana. Pakistan Journal of Biological Sciences, 14: 1019-1023.

DOI: 10.3923/pjbs.2011.1019.1023






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