
	Pakistan Journal of Biological Sciences
	Year: 2007 \| Volume: 10 \| Issue: 4 \| Page No.: 617-621 DOI: 10.3923/pjbs.2007.617.621

Prevention of CCl4-Induced Liver Damage by Ginger, Garlic and Vitamin E

K. C. Patrick-Iwuanyanwu, M. O. Wegwu and E. O. Ayalogu

Abstract: The hepatoprotective effects of garlic (Allium sativum), ginger (Zingiber officinale) and vitamin E pre-treatment against carbon tetrachloride (CCl₄)-induced liver damage in male wistar albino rats were investigated. Carbon tetrachloride (0.5 mL kg^-1 body weight) was administered after 28 days of feeding animals with diets containing ginger, garlic, vitamin E and various mixtures of ginger and garlic. Serum alanine amino transferase, aspartate amino transferase and alkaline phosphatase levels, 24 h after CCl₄ administration, decreased significantly (p≤0.05) in rats pre-treated with garlic, ginger, vitamin E and various mixtures of garlic and ginger than in CCl₄-treated rats only. Lipid peroxidation expressed by serum malondialdehyde (MDA) concentration was assayed to assess the extent of liver damage by CCl₄; including the extent of hepatoprotection by garlic, ginger and vitamin E. MDA concentration was significantly decreased (p≤0.05) in rats pretreated with garlic, ginger, vitamin E and various mixtures of garlic and ginger than in rats administered CCl₄-alone. Histological examination of the liver revealed severe infiltration of inflammatory cells in rats treated with CCl₄alone. However, the observed alteration in the normal architecture of the hepatic cells decreased remarkably in pre-treated rats.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Protective Effects of Curcumin and Ginger on Liver Cirrhosis Induced by Carbon Tetrachloride in Rats

•	Octreotide: A Somatostatin Analogue, Protects Liver against CCl₄-Induced Liver Injury in Mouse Model

•	Hepatoprotective Effects of African Locust Bean (Parkia clappertoniana) and Negro Pepper (Xylopia aethiopica) in CCl₄-Induced Liver Damage in Wistar Albino Rats

•	Hepatotoxic and Nephrotoxic Effects of Kerosene and Petrol-Contaminated Diets in Wistar Albino Rats

How to cite this article:

K. C. Patrick-Iwuanyanwu, M. O. Wegwu and E. O. Ayalogu, 2007. Prevention of CCl4-Induced Liver Damage by Ginger, Garlic and Vitamin E . Pakistan Journal of Biological Sciences, 10: 617-621.

DOI: 10.3923/pjbs.2007.617.621

URL: https://scialert.net/abstract/?doi=pjbs.2007.617.621

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI

Science Alert