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Pakistan Journal of Biological Sciences

Year: 2006 | Volume: 9 | Issue: 9 | Page No.: 1700-1706
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Authors

Sanaa A. Aly

Nagy S. El-Rigal

Maha Z. Rizk

Keywords

Research Article

Nutritional Supplementation with Ailanthus altissima and Ziziphus spina christi to Compensate for Some Metabolic Disorders in Schistosoma mansoni Infected Mice

Sanaa A. Aly, Nagy S. El-Rigal and Maha Z. Rizk
Different protein fractions having variable molecular weights were electrophoretically separated and quantitated in serum of control and S. mansoni infected mice with and without oral administration of chloroform extract of Alilanthus altissima stem bark and alcoholic extract of Ziziphus spina christi roots. Also total protein, alkaline phosphatase, cholesterol, bilirubin and nitric oxide levels were measured in sera of the same mice groups. The results obtained showed that administration of both extracts to normal mice increased total protein, albumin and most protein fractions. Also both extracts reduced alkaline phosphatase (ALP), cholesterol and nitric oxide (NO) while bilirubin was elevated. Infection with S. mansoni caused a decline in total protein and all protein fractions and an elevation in all other biochemical parameters with respect to control. However, administration of either extracts to infected mice upregulated the levels of the different parameters. It could be concluded that A. altissima and Z. spina christi extract supplements can compensate for the depletions in different proteins resulting by schistosomal infection and can also decrease liver disorders presumably due to their high nutritional value and their antioxidant and hepatoprotective constituents.
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