
	Pakistan Journal of Biological Sciences
	Year: 2003 \| Volume: 6 \| Issue: 22 \| Page No.: 1888-1890 DOI: 10.3923/pjbs.2003.1888.1890

In vitro Antimicrobial Activity of the Compound Isolated from Chloroform Extract of Moringa oleifera Lam.

Farjana Nikkon, Zahangir Alam Saud , M. Habibur Rahman and Md. Ekramul Haque

Abstract: The research work was conducted to investigate the in vitro antimicrobial activity of the compound Aglycon of Deoxy-Niazimicine (N-benzyl,S-ethyl thioformate) isolated from Moringa oleifera Lam. in comparison with crude chloroform extract. Antibacterial and antifungal activities of the compound-1 and crude extract were observed against fourteen pathogenic bacteria and six pathogenic fungi. Compound-1 isolated from the chloroform (CHCl₃) fraction of ethanol extract showed comparatively more in vitro antibacterial activity against Shigella boydii, Shigella dysenteriae and Staphylococcus aureus than the crude chloroform (CHCl₃) extract and produced zone of inhibition in between 09 and 13 mm. The MIC values of the compound-1 and crude extract were also determined against B. megaterium, St. aureus, Sh. dysenteriae and Sh. boydii. The values were found to be between 32 to 128 μg ml^-1. The compound-1 also showed moderate antifungal activity against Candida albicans and Aspergillus flavus than the crude chloroform extract although the crude extract showed moderate activity against Trichoderma species. Thus compound-1 has antibacterial and antifungal activity and suggested its therapeutic use as an antimicrobial agent.

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How to cite this article:

Farjana Nikkon, Zahangir Alam Saud , M. Habibur Rahman and Md. Ekramul Haque , 2003. In vitro Antimicrobial Activity of the Compound Isolated from Chloroform Extract of Moringa oleifera Lam.. Pakistan Journal of Biological Sciences, 6: 1888-1890.

DOI: 10.3923/pjbs.2003.1888.1890

URL: https://scialert.net/abstract/?doi=pjbs.2003.1888.1890

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