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Pharmacologia
  Year: 2018 | Volume: 9 | Issue: 2 | Page No.: 55-61
DOI: 10.5567/pharmacologia.2018.55.61
 
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Hepatoprotective Effects of Ethanol Extracts of Gongronema latifolium Leaves in a Carbon Tetrachloride (CCl4)-Induced Murine Model of Hepatocellular Injury
Chinyere Aloke , Peace Nzubechukwu Ogbodo and Chukwunonso E.C.C. Ejike

Abstract:
Background and Objective: Liver diseases are some of the commonest causes of death worldwide. Gongronema latifolium leaves are used in treatment of hepatic disorders in traditional medicine. The aim of this study was to assess the effect of ethanol leaf extracts of Gongronema latifolium (EEGL) on carbon tetrachloride (CCl4)-induced liver damage. Materials and Methods: Twenty five rats were divided into five groups of five rats each. Group I (vehicle control) received feed and water only. Groups II to V received a single dose of CCl4 in olive oil (1 mL kg–1 b.wt.) on day 7; while group II (positive control) were treated with the standard drug, silymarin (50 mg kg–1 b.wt.), and group III (negative control) were left untreated. Groups IV and V (test groups) were pre-treated with 200 and 400 mg kg–1 b.wt. doses of EEGL for seven consecutive days prior to CCl4 challenge. The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatases (ALP) and the concentrations of malondialdehyde (MDA) were determined in serum. Results: Pre-treatment with varied doses of the extract for seven days prior to CCl4 intoxication led to significant decrease (p<0.05) in activity of AST relative to negative control while there were non-significant (p>0.05) decreases in the activities of ALT and ALP. Malondialdehyde concentrations were decreased significantly (p<0.05) by 200 mg kg–1 b.wt. of EEGL when compared to the negative control. Conclusion: The results obtained from this study showed that EEGL might be useful for prevention of hepatotoxicity induced by CCl4 through reduction in oxidative stress.
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How to cite this article:

Chinyere Aloke, Peace Nzubechukwu Ogbodo and Chukwunonso E.C.C. Ejike, 2018. Hepatoprotective Effects of Ethanol Extracts of Gongronema latifolium Leaves in a Carbon Tetrachloride (CCl4)-Induced Murine Model of Hepatocellular Injury. Pharmacologia, 9: 55-61.

DOI: 10.5567/pharmacologia.2018.55.61

URL: https://scialert.net/abstract/?doi=pharmacologia.2018.55.61

 
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