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Pharmacologia
  Year: 2015 | Volume: 6 | Issue: 3 | Page No.: 97-105
DOI: 10.5567/pharmacologia.2015.97.105
 
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Protective Effects of Saponin-Rich Aqueous Leaf Extract of Gymnema sylvestre R. Br. against Cafeteria and High-Fat Diet-Induced Obesity and Oxidative Stress in Rats

Indireddy Rama Manohar Reddy, Pasupuleti Visweswara Rao, Bobbu Pushpa Latha and Tartte Vijaya

Abstract:
Background and Objectives: The present study was aimed to investigate the protective effect of saponin-rich aqueous leaf extract of Gymnema sylvestre (SGE) on obesity and oxidative stress in rats fed with cafeteria (CA) and high-fat (HF) diets. Methodology: Male Wistar rats were fed CA and HF diets for 8 weeks to induce obesity and oxidative stress. The SGE (100 mg kg-1) was administered orally to CA and HF fed rats for 8 weeks. Changes in body weight gain, food consumption, fat storage, serum parameters, fecal lipid excretion and liver oxidative stress parameters were measured. Results: SGE showed protective effect on body weight gain, food consumption and visceral fat accumulation. The SGE treatment elicited a significant reduction in serum levels of glucose, atherogenic index, total cholesterol, triglycerides, Low-Density Lipoproteins-Cholesterol (LDL-C), Very Low Density Lipoproteins-Cholesterol (VLDL-C) and while High-Density Lipoproteins-Cholesterol (HDL-C) level increased. Furthermore, SGE treatment decreased the liver lipids, lipid peroxidation and increased antioxidant levels and fecal lipid excretion in obese rats. Conclusion: In conclusion, intake of SGE may be a feasible therapeutic strategy for prevention of cafeteria and high-fat diet- induced obesity and oxidative stress.
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How to cite this article:

Indireddy Rama Manohar Reddy, Pasupuleti Visweswara Rao, Bobbu Pushpa Latha and Tartte Vijaya, 2015. Protective Effects of Saponin-Rich Aqueous Leaf Extract of Gymnema sylvestre R. Br. against Cafeteria and High-Fat Diet-Induced Obesity and Oxidative Stress in Rats. Pharmacologia, 6: 97-105.

DOI: 10.5567/pharmacologia.2015.97.105

URL: https://scialert.net/abstract/?doi=pharmacologia.2015.97.105

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