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Pharmacologia
  Year: 2013 | Volume: 4 | Issue: 5 | Page No.: 383-390
DOI: 10.5567/pharmacologia.2013.383.390
 
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Hepatoprotective Constituents from the Leaves of Pisonia grandis R.Br

Thenmozhi Shanmugam, Kameshwaran Sugavanam, Subasini Uthirapathi, Sathyamurthy Duraiswamy and Dhanalakshmi Manoharan

Abstract:
Objective: Pisonia grandis R.Br is a plant with a diversity of ethnic medicinal uses along with antioxidant activity. Hence we have intended to screen hepatoprotective activity with ethanolic (EEPG) and aqueous (AEPG) extracts of leaves of Pisonia grandis R.Br. Powder of leaves successively extracted with ethanol and aqueous solvents and it was subjected for phytochemical screening to categorize the different phytoconstituents. Materials and Methods: Hepatoprotective activity of both the extracts was studied against the liver injury induced by carbon tetrachloride, paracetamol or thioacetamide and chronic liver damage induced by carbon tetrachloride in rats. Results: Result showed that the extracts significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. EEPG at the dose of 250 mg kg-1, p.o.) prevented the increase in liver weight when compared to hepatoxin treated control, while the AEPG at the dose 250 mg kg-1 was ineffective except in the paracetamol induced liver damage. In the chronic liver injury induced by carbon tetrachloride, EEPG at the dose of 250 mg kg-1, p.o.) was found to be more effective than the AEPG 250 mg kg-1, p.o. Histological examination of the liver tissues supported the hepatoprotection. Conclusion: It is concluded that both extracts of leaves of Pisonia grandis R.Br possesses good hepatoprotective activity.
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How to cite this article:

Thenmozhi Shanmugam, Kameshwaran Sugavanam, Subasini Uthirapathi, Sathyamurthy Duraiswamy and Dhanalakshmi Manoharan, 2013. Hepatoprotective Constituents from the Leaves of Pisonia grandis R.Br. Pharmacologia, 4: 383-390.

DOI: 10.5567/pharmacologia.2013.383.390

URL: https://scialert.net/abstract/?doi=pharmacologia.2013.383.390

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