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Pharmacologia
  Year: 2013 | Volume: 4 | Issue: 3 | Page No.: 236-242
DOI: 10.5567/pharmacologia.2013.236.242
 
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Evaluation of Hepatoprotective Activity of Tecoma stans Flowers

S. Kameshwaran, A.R. Kothai, C. Jothimanivannan and R. Senthilkumar

Abstract:
Objective: Tecoma stans is a plant with a diversity of ethnic medicinal uses along with antioxidant activity. Hence, we have intended to screen hepatoprotective activity with ethanolic (EETS) extract of flowers of Tecoma stans. Methods: Powder of flower petals extracted with ethanol and it was subjected for phytochemical screening to categorize the different phytoconstituents. Hepatoprotective activity of the extract was studied against the liver injury induced by paracetamol, carbon tetrachloride, thioacetamide and chronic liver damage induced by carbon tetrachloride in rats. Results: The extract significantly reduced the elevated serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. EETS at the dose of 500 mg kg-1, p.o. prevented the increase in liver weight when compared to hepatoxin treated control while the extract at the dose 250 mg kg-1 was ineffective except in the paracetamol induced liver damage. In the chronic liver injury induced by carbon tetrachloride, EEPG at the dose of 500 mg kg-1, p.o. was found to be more effective than the extract at the dose of 250 mg kg-1, p.o.. Histological examination of the liver tissues supported the hepatoprotection. Conclusion: It is concluded that both extracts of flowers of Tecoma stans possesses good hepatoprotective activity.
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How to cite this article:

S. Kameshwaran, A.R. Kothai, C. Jothimanivannan and R. Senthilkumar, 2013. Evaluation of Hepatoprotective Activity of Tecoma stans Flowers. Pharmacologia, 4: 236-242.

DOI: 10.5567/pharmacologia.2013.236.242

URL: https://scialert.net/abstract/?doi=pharmacologia.2013.236.242

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