Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pharmacologia
  Year: 2011 | Volume: 2 | Issue: 6 | Page No.: 165-171
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Anti-inflammatory and Antioxidant Activities of Hunteria umbellata Seed Fractions

Adeneye A. Adejuwon, Sofidiya M. Oluwatoyin and Adenekan O. Sunday

Abstract:
Background: Decoction of Hunteria umbellata seeds is highly valued in African herbal medicine in the management of inflammation, diabetes and obesity. This study evaluates the anti-inflammatory and antioxidant activities of crude (HU) butanol (HUb) and alkaloid (HUAf) fractions of the water seed extract of Hunteria umbellata, in addition, to determining the phenolic content of HU and Hub. Materials and methods: The acute anti-inflammatory activity of 50 mg kg-1 of each of the seed fractions was evaluated in carrageenan-and formalin-induced oedematous Wistar rats. The fraction’s antioxidant activities were evaluated using 1,1-Diphenyl-2-picrylhydrazyl (DPPH) free radical, superoxide anions and nitric oxide scavenging methods, in addition, to determining the phenolic contents of the fractions using standard procedures. Results: Results showed that HU, HUb and HUAf significantly (p<0.05 and p<0.001) inhibited carrageenan-and formalin-induced inflammation in the rats. Similarly, HUb and HUAf at 0.2-0.8 mg mL-1 exhibited significant (p<0.05 and p<0.001) DPPH free radical, superoxide anion and nitric oxide scavenging activities with the most significant effect recorded for HUAf. Their proanthocyanidin contents were estimated to be 38.90±1.67 and 53.67±1.12 mg g-1 of dry extract, respectively while their total flavonoid contents were estimated to be 0.50±0.03 and 11.78±1.47 mg g-1 of dry extract, respectively. Also, their total phenolic contents were estimated to be 39.68±2.56 and 97.12±3.32 mg g-1 of dry extract. Conclusion: The anti-inflammatory activity of HU and its butanol fraction is attributed to its alkaloid content which was partly mediated via its anti-oxidant mechanism.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Antioxidant and Antibacterial Properties of Lecaniodiscus cupanioides
How to cite this article:

Adeneye A. Adejuwon, Sofidiya M. Oluwatoyin and Adenekan O. Sunday, 2011. Anti-inflammatory and Antioxidant Activities of Hunteria umbellata Seed Fractions. Pharmacologia, 2: 165-171.

URL: https://scialert.net/abstract/?doi=pharmacologia.2011.165.171

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
Curve Bottom