• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Kidney Research Journal
  2. Vol 1 (1), 2011
  3. 33-40
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Kidney Research Journal

Year: 2011 | Volume: 1 | Issue: 1 | Page No.: 33-40
DOI: 10.3923/krj.2011.33.40

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 175

Authors


E.A. Al-Omireeni

Country: Saudi Arabia

N.J. Siddiqi

Country: Saudi Arabia

A.S. Alhomida

Country: Saudi Arabia

Keywords


  • hydroxyproline
  • kidneys
  • Sodium fluoride
  • collagen
  • rats
Research Article

Effect of Different Doses of Sodium Fluoride on Various Hydroxyproline Fractions in Rat Kidneys

E.A. Al-Omireeni, N.J. Siddiqi and A.S. Alhomida
The present study was carried out to study the acute toxicity of various doses of sodium fluoride (NaF) on different hydroxyproline (HyP) fractions in rat kidneys. Five groups of rats were studied: (1) control rats, (2) rats divided into four subgroups according to the dose of NaF viz., rats were injected with a single intraperitoneal dose of 5, 10, 20 and 30 mg of Naf kg-1 b.wt./24 h. Results showed that protein-bound HyP fraction was most resistant to the effect of NaF. Doses of NaF caused significant changes (p<0.05) in other HyP fractions viz., free and peptide-bound HyP. Among the soluble and insoluble collagen HyP, it was soluble collagen Hyp which was significantly altered by NaF treatment (p<0.05). NaF treatment also caused significant (p<0.05) decrease in the protein content of rat kidneys. It is concluded that NaF treatment to rats caused a disturbance in connective tissue matrix of the kidneys in rats.
PDF Fulltext XML References Citation

How to cite this article

E.A. Al-Omireeni, N.J. Siddiqi and A.S. Alhomida, 2011. Effect of Different Doses of Sodium Fluoride on Various Hydroxyproline Fractions in Rat Kidneys. Kidney Research Journal, 1: 33-40.

DOI: 10.3923/krj.2011.33.40

URL: https://scialert.net/abstract/?doi=krj.2011.33.40

Related Articles

The Acute Toxicity of Deisopropylngaione in Mice
Effect of Long-term Pumping on Fluoride Concentration Levels in Groundwater: A Case Study from East of Blue Nile Communities of Sudan
Des Disease Status and Steroid Responsivenoess in Idiopathic Nephrotic Syndrome Depend on ACE I/D Gene Polymorphism? A Study from South India
Biochemical Changes in the Liver and the Pancreas of Well-fed and Protein Undernourished Rats Following Fluoride Administration

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved