
	Kidney Research Journal
	Year: 2011 \| Volume: 1 \| Issue: 1 \| Page No.: 33-40 DOI: 10.3923/krj.2011.33.40

Effect of Different Doses of Sodium Fluoride on Various Hydroxyproline Fractions in Rat Kidneys

E.A. Al-Omireeni, N.J. Siddiqi and A.S. Alhomida

Abstract: The present study was carried out to study the acute toxicity of various doses of sodium fluoride (NaF) on different hydroxyproline (HyP) fractions in rat kidneys. Five groups of rats were studied: (1) control rats, (2) rats divided into four subgroups according to the dose of NaF viz., rats were injected with a single intraperitoneal dose of 5, 10, 20 and 30 mg of Naf kg^-1 b.wt./24 h. Results showed that protein-bound HyP fraction was most resistant to the effect of NaF. Doses of NaF caused significant changes (p<0.05) in other HyP fractions viz., free and peptide-bound HyP. Among the soluble and insoluble collagen HyP, it was soluble collagen Hyp which was significantly altered by NaF treatment (p<0.05). NaF treatment also caused significant (p<0.05) decrease in the protein content of rat kidneys. It is concluded that NaF treatment to rats caused a disturbance in connective tissue matrix of the kidneys in rats.

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How to cite this article:

E.A. Al-Omireeni, N.J. Siddiqi and A.S. Alhomida, 2011. Effect of Different Doses of Sodium Fluoride on Various Hydroxyproline Fractions in Rat Kidneys. Kidney Research Journal, 1: 33-40.

DOI: 10.3923/krj.2011.33.40

URL: https://scialert.net/abstract/?doi=krj.2011.33.40

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