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Journal of Pharmacology and Toxicology

Year: 2011 | Volume: 6 | Issue: 8 | Page No.: 691-700
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Authors

A. Balouchzadeh

H.R. Rahimi

A.R. Ebadollahi-Natanzi

B. Minaei-Zangi

O. Sabzevari

Keywords

The aim of this study was to examine the protective effects of Iranian green tea aqueous extract (GTE) (Camellia sinensis) in chronic ethanol toxicity using rat model. Animals were divided into four groups and fed for 30 days by gavage technique: A (Control), B (Ethanol-15% (v/v)), C (Ethanol + GTE) and D (GTE-2.5% (w/v)). Aspartate aminotransferase (AST, 158%), alanine aminotransferase (ALT, 131%), alkaline phosphatase (ALP, 159%), γ-glutamyltranspeptidase (GGT, 89%) and malondialdehyde (MDA, 53%) values were significantly (p<0.01) increased in the ethanol group (B) as compared to the control (A). Treatment of animals with GTE, however, considerably (p<0.05) protected the liver damage by decreasing AST (32%), ALT (33%), ALP (26%), GGT (47%) and MDA (59%) values. GSH concentration was significantly decreased in the ethanol group as compared to the control (40%) but considerably recovered (58%) following GTE treatment. Furthermore, histopathological observations, consistent with biochemical findings, showed that GTE treatment significantly reduced portal inflammation and infiltration of mononuclear cells pronounced by ethanol.
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