Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 8 | Page No.: 647-663
DOI: 10.3923/jpt.2011.647.663
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

The Protective Role of Coffea arabica L. and Crocus sativus L. Against the Neurotoxicity Induced by Chronic Administration of Aluminium Chloride
Fahmy G. Elsaid, Ali A. Shati and Elsayed E. Hafez

Abstract: Aluminium (Al) affects the antioxidant/oxidant balance and several enzymes relevant to neurotoxicity. Natural products such as saffron and green coffee may have a pharmacological role in ameliorating the neurotoxicity induced by Al as a result of their antioxidant properties. The study aims to investigate the role of saffron and green coffee extracts in ameliorating the toxicity induced by aluminium chloride in the nervous tissues of rats. Sprague dawley rats were used in this study and divided into 6 groups: control group; Green coffee group (600 mg/kg b.w./day for 90 days); Saffron group,(200 mg/kg b.w./day; AlCl3 group,(40mg/kg b.w./day of AlCl3 for 90 days); AlCl3 plus green coffee group, co-administered with 40 mg/kg b.w./day of AlCl3 and green coffee extract at 600 mg/kg b.w./day; AlCl3 plus saffron group,(40 mg/kg b.w./day) of AlCl3 and aqueous saffron extract (200 mg/kg b.w./day). There was a decrease in the AChE activity in rats administered with AlCl3 for 90 days. Additionally, there was a decrease in the enzymatic antioxidant activities in both cerebral hemisphere and cerebellum of rats in AlCl3 group. At the molecular level, the expression of A Disintegrin And Metalloprotease (ADAM10), acetylcholinesterase, P53, Bcl-2 (B cell lymphoma 2) and interleukins (IL-4 and IL-12) genes in AlCl3 group was changed. Both green coffee and saffron extracts could be used to attenuate the neurotoxic effects of AlCl3 as the imbalance in antioxidants/oxidants system and in some genes expression.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effect of Methanolic Leaf Extract of Ocimum gratissimum (Linn) Leaves on Sodium Arsenite-Induced Toxicity in Rats
  •    Effect of Repeated Administration of Paeonia emodi Wall Root Extract in Experimental Models of Epilepsy and Behavior
How to cite this article:

Fahmy G. Elsaid, Ali A. Shati and Elsayed E. Hafez, 2011. The Protective Role of Coffea arabica L. and Crocus sativus L. Against the Neurotoxicity Induced by Chronic Administration of Aluminium Chloride. Journal of Pharmacology and Toxicology, 6: 647-663.

DOI: 10.3923/jpt.2011.647.663

URL: https://scialert.net/abstract/?doi=jpt.2011.647.663
COMMENT ON THIS PAPER
 
 
 

 
  Bullet Navigation
 
  Page Icon Online First
  Page Icon Current Issue
  Page Icon Previous Issues
  Page Icon Editorial Board
  Page Icon Submit a Manuscript
  Page Icon Guide to Authors
  Page Icon Subscribe to E-alerts

  Bullet Indexed In
 
  Page Icon ASCI-Database
  Page Icon Asian Digital Library
  Page Icon Cambridge Scientific Abstract
  Page Icon Chemical Abstract Services
  Page Icon Google Scholar

Science Alert
Curve Bottom