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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 6 | Page No.: 580-588
DOI: 10.3923/jpt.2011.580.588
 
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Phytopharmacological Evaluation of Ethanolic Extract of the Seeds of Abrus precatorius Linn

Rashmi Arora, Naresh Singh Gill, Sukhwinder Kaur and Ajay Deep Jain

Abstract:
Abrus precatorius Linn. is a leguminous plant of the fabaceae family whose stem, bark, leave and roots are widely used for medicinal purposes in tropical and subtropical regions of the world. The plant parts are purgative, emetic, tonic, anti-phlogistic, aphrodisiac and anti-ophthalmic agents. The purpose of the present investigation was to study antioxidant, anti-inflammatory and analgesic activity of Abrus precatorius Linn. ethanolic seed extracts by soxhlet method. The free radical scavenging activity of extract was carried out by 1,1-diphenyl-2-picrylhydrazyl method and anti-inflammatory activity by carrageenan induced rat paw edema and analgesic activity carried out by tail flick and tail immersion method. The extract showed significant activity i.e., 80.1±0.34% at 300 μg mL-1. The extract was evaluated for its anti-inflammatory activity it showed significant anti-inflammatory activity i.e., 62.68% at 375 mg kg-1 by carrageen induced method. Further, the extract was evaluated for analgesic activity and the extract showed significant activity at 300 mg kg-1 after 90 min interval by tail flick and tail immersion method. As ethanolic extract of Abrus precatorius Linn. was found to have potent antioxidant, anti-inflammatory and analgesic potential. The present study concludes that seeds of Abrus precatorius Linn. can be used as good natural antioxidant to treat free radical induced disease.
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How to cite this article:

Rashmi Arora, Naresh Singh Gill, Sukhwinder Kaur and Ajay Deep Jain, 2011. Phytopharmacological Evaluation of Ethanolic Extract of the Seeds of Abrus precatorius Linn. Journal of Pharmacology and Toxicology, 6: 580-588.

DOI: 10.3923/jpt.2011.580.588

URL: https://scialert.net/abstract/?doi=jpt.2011.580.588

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