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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 5 | Page No.: 481-492
DOI: 10.3923/jpt.2011.481.492
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Ameliorative Effect of Vitamin E on Chemotherapy Induced Side Effects in Rat Liver

K.C. Singh, R. Kaur and T. Marar

The aim of the study was to evaluate the extent of change in activities of antioxidant enzymes and lipid peroxidation caused by CPT and protective efficacy of Vitamin E over detrimental effects induced by CPT in male Wistar rat. Male Wistar rats 120±20 g were categorized in four groups. Two groups of rats were administered with CPT (6 mg kg-1 intravenously for 4 days); one of these groups received Vitamin E (oral dose of 6 mg kg-1 for 30 days) prior to CPT injections. A vehicle treated control group and a Vitamin E control group were also included. CPT treated rats showed significant increase in lipid peroxidation and glycogen levels when compared to control rats. In rats treated with CPT, abnormal changes in activities of enzymic (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase) and non-enzymic (reduced glutathione and Vitamin E) antioxidants were observed. Liver of CPT treated rats showed significant decrease in diagnostic marker enzymes such as aspartate aminotransferase and alanine aminotransferase accompanied with significant increase in alkaline phosphatase and lactate dehydrogenase levels. Pretreatment with Vitamin E reduced the oxidative stress and change in activity of antioxidant enzymes induced by CPT, thereby demonstrating the protection rendered by Vitamin E. Result of the present study suggests that Vitamin E administrated orally protected against oxidation in our experimental models and could be one approach to reducing the risk of CPT-induced side effects in clinical settings.
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How to cite this article:

K.C. Singh, R. Kaur and T. Marar, 2011. Ameliorative Effect of Vitamin E on Chemotherapy Induced Side Effects in Rat Liver. Journal of Pharmacology and Toxicology, 6: 481-492.

DOI: 10.3923/jpt.2011.481.492






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