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Journal of Pharmacology and Toxicology

Year: 2011 | Volume: 6 | Issue: 4 | Page No.: 427-432
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Authors

H. Sheth

D.K. Suresh

R. Hasan

Md S. Khalid

S. Mahesh

Keywords

Research Article

Influence of Bosentan on Antidiabetic Effect of Pioglitazone and Nateglinide in Experimental Animals

H. Sheth, D.K. Suresh, R. Hasan, Md S. Khalid and S. Mahesh
The present study was carried out to evaluate the drug-drug interaction between antidiabetic drugs and antihypertensive drug. Interaction of Pioglitazone, the known Thiazolidinedione antidiabetic drug and Nateglinide, the known Meglitinide class antidiabetic drug with Bosentan, an antihypertensive drug was evaluated in healthy and Streptozotocin (STZ) induced diabetic rats. The blood samples were collected from rats at different time interval upto 24 h and blood glucose was estimated. Bosentan (10 mg kg-1, p.o.) pretreatment has not significantly altered the onset of antidiabetic effect of Pioglitazone (0.3 mg kg-1, p.o.) but significantly decreased the peak antidiabetic effect in healthy and Streptozotocin induced diabetic rats (44.74±2.56% reduction before treatment to 34.59±0.25% reduction after treatment), while duration of antidiabetic effect was reduced from 16 h to less than 12 h in both groups. Similarly pretreatment with Bosentan (10 mg kg-1, p.o.) has significantly no effect on the onset of antidiabetic effect of Nateglinide (50 mg kg-1, p.o.) but it significantly reduced the peak antidiabetic effect in healthy and Streptozotocin induced diabetic rats (46.15±1.25% reduction before treatment to 37.57±1.61% reduction after treatment), while duration of antidiabetic effect was reduced from 12 h to less than 8 h in both groups. This study indicates that Therapeutic Drug Monitoring (TDM) has to be required to readjust the therapeutic doses of Bosentan and antidiabetic drugs like Pioglitazone and Nateglinide when they used concomitantly.
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