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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 2 | Page No.: 166-173
DOI: 10.3923/jpt.2011.166.173
 
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Subacute and Subchronic Toxicity Studies of Palm Vitamin E in Mice

S. Ima-Nirwana, Y. Nurshazwani, A.S. Nazrun, M. Norliza and M. Norazlina

Abstract:
Palm oil is a rich source of vitamin E, especially the tocotrienols. It had been shown in previous studies to be effective in preventing and treating experimentally induced osteoporosis in laboratory rats. The objective of this study was to determine the subacute and subchronic toxic effects of palm vitamin E extract on mice. This was part of an ongoing effort to determine the potential for use of palm vitamin E as an anti-osteoporotic agent. The doses used in this study were 200, 500 and 1000 mg kg-1. Treatment period was 14 days for the Subacute Toxicity Study and 42 days for the Subchronic Toxicity Study. The parameters measured were Bleeding Time, Clotting Time, serum aspartate aminotransferase, serum creatinine as well as liver and kidney weights. The results showed that the Bleeding and Clotting Times were significantly prolonged in the 500 and 1000 mg kg-1 groups in both the Subacute and Subchronic Toxicity Studies. Serum creatinine was raised in the 500 and 1000 mg kg-1 group for the Subchronic Toxicity Study. Kidney weights were increased in the 200 and 500 mg kg-1 groups for the Subacute Toxicity Study and in the 1000 mg kg-1 group for the Subchronic Toxicity Study. No changes in serum aspartate aminotransferase levels or in liver weights were seen in both the Subacute and Subchronic Toxicity Studies. In conclusion, large doses of palm vitamin E in animals well above the effective dose used to prevent and treat osteoporosis may cause bleeding tendency and renal impairment but there was no liver toxicity.
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How to cite this article:

S. Ima-Nirwana, Y. Nurshazwani, A.S. Nazrun, M. Norliza and M. Norazlina, 2011. Subacute and Subchronic Toxicity Studies of Palm Vitamin E in Mice. Journal of Pharmacology and Toxicology, 6: 166-173.

DOI: 10.3923/jpt.2011.166.173

URL: https://scialert.net/abstract/?doi=jpt.2011.166.173

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