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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 2 | Page No.: 158-165
DOI: 10.3923/jpt.2011.158.165
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Metabolic Profile of Rats after One Hour of Intoxication with a Single Oral Dose of Ethanol

Manal A Hamed

The objective of this study was to mointer the metabolic disturbance in rats one hour after intoxication with one oral dose of ethanol. Rats orally administered with 10 g ethanol/kg body weight on 24 h empty stomach and sacrificed one hour later. Intoxicated rats recorded significant increase in blood alcohol level (alcohol dehydrogenase; ADH), aspartate (AST) and alanine (ALT) aminotransferase, lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) enzyme activities. Carbohydrate deficient transferrin (CDT) level as a new marker for detection early independent ethanol intoxication recorded significant increase. Serum transferrin content was evaluated to avoid the false positive results of CDT. In conclusion, AST, ALT, LDH and GGT may be used as biomarkers for early diagnosis of ethanol toxicity. CDT plays a promise role for early diagnosis. CDT and the other biochemical tests especially GGT are recommended to be detected in parallel to improve the performance of either marker used alone.
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  •    Estimating the Plasma and Serum Activity Levels of Aspartate Aminotransferase and Alanine Aminotransferase, in Live Animals Using Regression Model
  •    Changes in Rabbit Liver Function Markers after Chronic Exposure to Ethanol
  •    Gastroprotective Effects of Aqueous Extract of Adansonia digitata Leaf on Ethanol-Induced Ulceration in Rats
  •    Hepatoprotective Effect of Carnosine on Liver Biochemical Parameters in Chronic Ethanol Intoxicated Rat
How to cite this article:

Manal A Hamed , 2011. Metabolic Profile of Rats after One Hour of Intoxication with a Single Oral Dose of Ethanol. Journal of Pharmacology and Toxicology, 6: 158-165.

DOI: 10.3923/jpt.2011.158.165






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