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Journal of Pharmacology and Toxicology

Year: 2010 | Volume: 5 | Issue: 7 | Page No.: 334-342
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Authors

S.A. Ganie

E. Haq

A. Masood

M.A. Zargar

Keywords

Research Article

Antioxidant Activities of Methanolic Rhizome Extract of Podophyllum Hexandrum Against CCl4-Induced Kidney and Lung Injury in Rats

S.A. Ganie, E. Haq, A. Masood and M.A. Zargar
The aim of the study was to evaluate the effect of methanolic rhizome extract of Podophyllum hexandrum treatment on the amelioration of CCl4 induced oxidative stress in albino rats. Exposure to CCl4 is known to induce acute and chronic kidney and lung injuries. The antioxidant capacity of Podophyllum hexandrum in the CCl4 treated rat kidney and lung tissues was monitored by assaying the activities of different antioxidant enzymes viz., Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Glutathione reductase (GR) and Glutathione S-transferase (GST). Also the effect of Podophyllum hexandrum on the levels of thiobarbituric acid reactive species (TBARS), reduced-glutathione (GSH) was monitored. It was found that methanolic extract of Podophyllum hexandrum could ameliorate the lung and kidney damage in these rats as was evident by the antioxidant status of the above mentioned parameters. Thus Podophyllum hexandrum has potential anti-oxidant effects, against the free radical mediated damages.
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