Research Article

**Evaluation of Toxicological Activity (Acute and Sub-Chronic Toxicities) of the Aqueous Extract of Lawsonia inermis Seeds on Wistar Rats**

E.H. Abdelgadir, R.H. Ahmed, S.I.Y. Adam and A.M. Husein

This study was carried out on the effect of aqueous extract of Lawsonia inermis seeds on rats. The 78.57 mg kg^-1 of the extract administered for 4 weeks, caused body weight gain to rats and a significant decrease on hematological parameters and potassium concentration. Also there was a significant increase in the AST, ALP, total protein, albumin and urea concentrations with no obvious histopathological changes. 78.57, 392 and 785.7 mg/kg/day administered orally to rats for 1 week, caused an increase in AST, ALP and total protein concentrations. 785.7 mg kg^-1 of the extract caused an increase in the ALT activity and a decrease in the potassium concentration. 78.57 and 785.7 mg kg^-1 of the extract caused an increase in urea and cholesterol concentrations, while 392 and 785.7 mg kg^-1 of the extract had caused hepatocytic necrosis, dilatation of the renal tubules and desquamation of the intestinal epithelium.

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E.H. Abdelgadir, R.H. Ahmed, S.I.Y. Adam and A.M. Husein, 2010. Evaluation of Toxicological Activity (Acute and Sub-Chronic Toxicities) of the Aqueous Extract of Lawsonia inermis Seeds on Wistar Rats. Journal of Pharmacology and Toxicology, 5: 324-333.

DOI: 10.3923/jpt.2010.324.333

URL: https://scialert.net/abstract/?doi=jpt.2010.324.333

Journal of Pharmacology and Toxicology

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Authors

E.H. Abdelgadir

R.H. Ahmed

S.I.Y. Adam

A.M. Husein

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Research Article

**Evaluation of Toxicological Activity (Acute and Sub-Chronic Toxicities) of the Aqueous Extract of Lawsonia inermis Seeds on Wistar Rats**

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