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Journal of Pharmacology and Toxicology

Year: 2008 | Volume: 3 | Issue: 6 | Page No.: 435-448
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Authors

A.P.M. Rocha

A.C. Resende

M.A.V. Souza

L.C.R.M. Carvalho

P.J.C. Sousa

T. Tano

D.N. Criddle

L.C. Porto

S.S. Valenca

R.S. de Moura

Keywords

Earlier, we have demonstrated that a hydro-alcoholic extract of the stone of Euterpe oleracea Mart., commonly known as Acai, exerts a significant endothelium-dependent vasodilator action in vitro. The present study has evaluated potential antihypertensive proprieties of Acai Stone Extract (ASE) in four established models of experimental hypertension in the rat; spontaneously hypertensive rats (adult and young 21 days of age SHR), Goldblatt (2 kidney, 1-clip; 2K-1C), l-NAME and DOCA-salt-induced hypertension. Blood pressure was measured non-invasively using the tail-cuff method. A significant antihypertensive effect of ASE (200 mg/kg/day) was observed in adult SHR, Goldblatt, l-NAME and DOCA-salt models of hypertension. Administration of ASE just after weaning prevented the development of hypertension in SHR. Interestingly, expression of eNOS (endothelial nitric oxide synthase), which was elevated in SHRs compared to normontensive rats, was reduced in SHRs by ASE treatment. In addition, a significant antioxidant action of ASE, evaluated by TBARS measured in the bronchoalveolar lavage of rats exposed to cigarette smoke, was observed. In conclusion, the present study has demonstrated an antihypertensive action of ASE that is probably mediated via its vasodilator and antioxidant actions and the current preclinical data suggest a potential therapeutic use of ASE in hypertensive patients.
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How to cite this article

A.P.M. Rocha, A.C. Resende, M.A.V. Souza, L.C.R.M. Carvalho, P.J.C. Sousa, T. Tano, D.N. Criddle, L.C. Porto, S.S. Valenca and R.S. de Moura, 2008. Antihypertensive Effects and Antioxidant Action of a Hydro-Alcoholic Extract Obtained from Fruits of Euterpe oleracea Mart. (Acai). Journal of Pharmacology and Toxicology, 3: 435-448.

DOI: 10.3923/jpt.2008.435.448

URL: https://scialert.net/abstract/?doi=jpt.2008.435.448

Comments

JERRY ASIEDU-LARBI Reply

Dear sirs,
I think your work is just what ihave been waiting for. I am Ghanaian Ph.D student in Biochemistry with herbal antihypertensive being my research interest. I am having problems measuring BP with the tail-cuff method. I don,t know how much to warm the rats if at all. Also, i do not know how to estimate the BP using the cursor on the monitor. I would greatly appreciate it if you could offer me some knowledge.

Thank you and waiting for oyur response
Jerry

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