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Ameliorative Effect of Ficus hispida Linn. Leaf Extract on Cyclophosphamide-Induced Oxidative Hepatic Injury in Rats |
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T.S. Shanmugarajan,
M. Arunsundar,
I. Somasundaram,
D. Sivaraman,
E. Krishnakumar and V. Ravichandran |
Abstract:
The current study was designed to scrutinize the putative
hepatoprotective potential of the methanolic leaf extract of Ficus
hispida Linn. (FH) (400 mg kg-1 body weight) on cyclophosphamide
(CP) elicited oxidative injury in rat liver. CP administration (150 mg
kg-1 body weight, i.p., twice, in 2 consecutive days) caused
liver injury, featuring substantial increase in serum aspartate transaminase
(AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate
dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT) and bilirubin
levels. In contrast, treatment with FH significantly precluded all these
alterations. CP intoxicated rats depicted a remarkable oxidative stress,
as evidenced by a significant elevation in lipid peroxidation (LPO) with
a concomitant decrease in the GSH activity. These changes were coupled
with a marked decline in the activities of enzymic antioxidants [superoxide
dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase
(GST) and glutathione reductase (GR)] in the liver tissue of CP-administered
rats. FH treated rats displayed a significant inhibition of lipid peroxidation
(LPO) and augmentation of endogenous antioxidants. Taken together, these
findings emphasize the hepatoprotective effect of F. hispida
leaf extract against CP-induced oxidative liver injury. Hence, F.
hispida might serve as a promising medicinal herb in complementary
chemotherapeutic modalities.
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How to cite this article:
T.S. Shanmugarajan, M. Arunsundar, I. Somasundaram, D. Sivaraman, E. Krishnakumar and V. Ravichandran, 2008. Ameliorative Effect of Ficus hispida Linn. Leaf Extract on Cyclophosphamide-Induced Oxidative Hepatic Injury in Rats. Journal of Pharmacology and Toxicology, 3: 363-372.
DOI: 10.3923/jpt.2008.363.372
URL: https://scialert.net/abstract/?doi=jpt.2008.363.372
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