Submit Manuscript

Journal of Pharmacy and Allied Health Sciences

Year: 2012 | Volume: 2 | Issue: 1 | Page No.: 12-20
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 1296

Authors

O.O. Olajuyigbe

Keywords

Research Article

Synergistic Influence of Tetracycline on the Antibacterial Activities of Amoxicillin Against Resistant Bacteria

O.O. Olajuyigbe
In this study, the in vitro influence of antibacterial activity of amoxicillin and tetracycline on each other was investigated by macrobroth dilution and checkerboard assay methods. Each of the antibiotics as well as their combinations proved inhibitory against all the tested organisms with the exception of Acinetobacter calcoaceticus showing high level of resistance. The inhibition zones produced by the combination of tetracycline and amoxicillin with those obtained from each antibiotic showed synergistic interaction which is concentration dependent. The checkerboard assay results showed 87.5 synergy and 12.5% antagonism with a high reduction in the Minimum Inhibitory Concentrations (MICs) and a strong bactericidal activity against the test organisms. Results of macrobroth dilution and checkerboard assays are complementary and indicated a strong synergistic interaction between amoxicillin and tetracycline.
PDF Fulltext XML References Citation

Related Articles

In vitro Binding Chemistry of Amlodipine Besylate (Calcium Channel Blocker) and Atorvastatin Calcium (HMG-CoA Reductase Inhibitor) to Serum Albumin and their Mutual Effect to Displace Each Other from the Binding Site
Prevalence of Extended Spectrum Beta Lactamases in Uropathogenic Escherichia coli and Klebsiella Species in a Chennai Suburban Tertiary Care Hospital and its Antibiogram Pattern
Effects of Onion on Serum Uric Acid Levels and Hepatic Xanthine Dehydrogenase/Xanthine Oxidase Activities in Hyperuricemic Rats
Antibiotic Resistance in Urinary Tract Bacteria in Ouagadougou
Comparative Study of Clozapine, Electroshock and the Combination of ECT with Clozapine in Treatment-Resistant Schizophrenic Patients

Leave a Comment

Your email address will not be published. Required fields are marked *