
	Journal of Medical Sciences
	Year: 2014 \| Volume: 14 \| Issue: 1 \| Page No.: 46-50 DOI: 10.3923/jms.2014.46.50

Spermatotoxicity in Animal Models Exposed to Fragrance Components

G.G. Akunna, L.C. Saalu, B. Ogunlade and L.A. Enye

Abstract: Various commonly-used products have been reported to contain chemicals that could disrupt estrogen and testosterone hormone. As trade secrets, these chemicals are generally listed as fragrance to mask individual identity. In this study, the reproductive implications of two commonly used perfumes (designated as F1 and F2) in Nigeria were carried out. Sixty adult male wistar rats (12-13 weeks old) were randomly divided into four groups (A-F) of ten rats each. Group A and B rats were exposed to 5 mL kg^-1 b.wt. of normal saline for 56 days and 112 days, respectively via whole body inhalation. Group C and D rats were exposed to 5 mL kg^-1 b.wt. of a fragrance product designated as F1 for a period of 56 days and 112 days, respectively while Group E and Group F rats were exposed to 5 mL kg^-1 b.wt. of a designated fragrance product F2 for a period of 56 days and 112 days, respectively. The results obtained from this study showed a significant (p<0.005) decrease in body weight and absolute testicular weight of the rat models exposed to fragrance when compared to the control groups. It was also observed that the concentration, mobility, livability and morphology of spermatozoa from groups C, D, E and F were significantly lower (p>0.005) when compared to values of the control group A and B. Based on the spermiographic evaluation from this study, fragrance materials could have an adverse effect on spermatozoa of the intact male wistar rats.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Evidences for Spermatozoa Toxicity and Oxidative Damage of Cadmium Exposure in Rats

•	The Effects of Two Nigerian Made Perfumes on the Liver of Adult Wistar Rat

•	An Evaluation of Influence of Citrus paradisi Seed Extract on Doxorubicin-Induced Testicular Oxidative Stress and Impaired Spermatogenesis

•	Ethanolic Seed Extract of Grapefruit (Citrus paradisi Macfad) as an Effective Attenuator of Doxorubicin-Induced Oxidative Stress in the Rat Heart

How to cite this article:

G.G. Akunna, L.C. Saalu, B. Ogunlade and L.A. Enye, 2014. Spermatotoxicity in Animal Models Exposed to Fragrance Components. Journal of Medical Sciences, 14: 46-50.

DOI: 10.3923/jms.2014.46.50

URL: https://scialert.net/abstract/?doi=jms.2014.46.50

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		ASCI-Database
		Asian Digital Library
		EMBASE
		Google Scholar

Science Alert