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Journal of Medical Sciences

Year: 2014 | Volume: 14 | Issue: 4 | Page No.: 174-178
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Authors

I.U. Ebong

N.C. Osuchukwu

E.U. Ebong

Keywords

Research Article

Liver Enzymes and Hematological Effect of Sub-chronic Periwinkle (Pachymelania aurita) and Rock Snail (Thais coronata) Consumption in Anaemic Albino Rats

I.U. Ebong, N.C. Osuchukwu and E.U. Ebong
To investigate the effect of sub chronic consumption of Periwinkle and Rock snail extracts on liver enzymes and blood in anaemic albino rats was the objective of this study. Twenty-five male and female albino rats were randomly used in the study and were divided into three groups. Anaemia was first introduced into twenty rats after strict corn-meal feeding for three weeks. Group one (5 rats) served as control (normal rat feed and water); group two (10 rats)-anaemic+rat feed and periwinkle extract; group three (10 rats)-anaemic+rat feed and rocksnail extracts. After three weeks, the rats were sacrificed and their blood taken for analysis. In the test for anemia, the result indicated that the rat was anaemic. There was decrease in the blood parameters (Red blood cell, White blood cell, hemoglobin, Pack cell volume) when compared with control at p<0.001. The results for serum AST, ALT and ALP level from anaemic-rock snail fed rats revealed that there was significant decrease (p<0.05) in liver enzyme level when compared with the control. This was similar with anaemic-periwinkle extract-fed rats except in ALP level which was significantly increased (p<0.05) when compared with control. Similarly, there was significant increase in the blood parameters (RBCs, WBCs, Hb Concentration and PCV) and also differential WBC counts from anaemic extracts-fed rats when compared with control rats. This result reveals that subchronic consumption of rock snail and periwinkle extracts on anemic liver enzymes shows no deleterious effect on the liver enzymes and there was also improved state of the blood cells counts.
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