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Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 6 | Page No.: 446-452
DOI: 10.3923/jms.2013.446.452
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Pineapple Juice Administration and Gastric Ulcer in Wistar Rats

O.A. Oyesola, T.O. Oyesola and A.I. Izagbo

Fruits have been part of the human diet and supplements. Present study was conducted to investigate pineapple juice (PJ) effects on Gastric Ulcer (GU), since dietary substances or supplements may predispose someone to GU. Thirty-six male wistar rats, weighing 180-200 g were used. They were divided into six groups A-F. Groups A served as control. Group B was not given PJ. Groups C-F received 0.5, 1.0, 1.5 and 2 mL of PJ, respectively. After 30 days, GU was induced with indomethacin. Ulcers Indices (UI) were scored, Total Protein Content (TPC), Catalase (CAT), Superoxide Dismutase (SOD) activities and Lipid Peroxidation (LPP) were determined from stomachs’ tissue. Significances were taken at p<0.05. UI showed significant increases when groups B-F were compared with control. A significant reduction was seen in TPC when groups B-F were compared with control. Comparison of CAT activities between control and groups B-F showed significant reduction in groups B-F and a significant increase in SOD in groups B-F. Activities of anti-oxidant enzymes in group B were compared with groups C-F. Observation showed that CAT activity increased significantly in groups C and D and SOD activity reduced significantly in groups D-F. Observation from LPP in the gastric mucosa showed increase which was significant in group B, when control was compared with groups B-F. When group B was compared with groups C-F, significant increases were observed in groups C and D. Conclusion from results suggested that PJ consumption may predispose, consumer to gastric ulceration because of its tendency to reduce TPC, increase UI and anti-oxidant enzymes.
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  •    Potentiation of Gastric Ulceration by Experimental Lead Exposure in Rats
  •    Therapeutic Application of Pineapple Protease (Bromelain): A Review
How to cite this article:

O.A. Oyesola, T.O. Oyesola and A.I. Izagbo, 2013. Pineapple Juice Administration and Gastric Ulcer in Wistar Rats. Journal of Medical Sciences, 13: 446-452.

DOI: 10.3923/jms.2013.446.452


20 June, 2017
Nancy plawecki:
I find your article very interesting. However, not plain enough for regular readers who don't have chem back grounds or lab. I love pineapple and have stomach issues. Suggestions,?




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