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Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 1 | Page No.: 28-35
DOI: 10.3923/jms.2013.28.35
 
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Nutritional Modulation of Hematological Indices in Malaria: In vivo Study in Plasmodium berghei Infected Mice

O.I. Iribhogbe, E.O. Agbaje, I.A. Oreagba, O.O. Ain and A.D. Ota

Abstract:
Malaria infection has been associated with a decrease in hematological parameters. This is linked to micronutrient deficiency which is associated with increasing severity of infection. The present study involves an in vivo evaluation of the role of some selected antioxidant micronutrients in the modulation of hematological profile in malaria infection. Rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. A 4 day curative test was conducted using 45 mice of either sex with a mean weight of 20.05±0.02 g. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 h post inoculation. Results showed a statistically (p<0.05) significant difference in total White Blood Cell count (WBC) in the vitamin A, E, selenium and zinc treated groups when compared with apparently healthy non-inoculated control. Additionally, there was a significant increase in MCHC in the zinc treated group when compared to apparently healthy uninfected control (34.21±0.29 g dL-1 versus 31.88±0.63 g dL-1; p<0.05). In conclusion, use of antioxidant micronutrients as adjuvant may help improve hematological parameters in malaria induced anemia in addition to modulating cell mediated immune response.
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How to cite this article:

O.I. Iribhogbe, E.O. Agbaje, I.A. Oreagba, O.O. Ain and A.D. Ota, 2013. Nutritional Modulation of Hematological Indices in Malaria: In vivo Study in Plasmodium berghei Infected Mice. Journal of Medical Sciences, 13: 28-35.

DOI: 10.3923/jms.2013.28.35

URL: https://scialert.net/abstract/?doi=jms.2013.28.35

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