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Journal of Medical Sciences

Year: 2013 | Volume: 13 | Issue: 3 | Page No.: 160-168
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Authors

Mohammed A. Ibrahim

Kalkunte S. Srivenugopal

Kakil Ibrahim Rasul

Keywords

Active platinum compounds have important applications in treatment of number of malignant tumors and are used in the treatment of lung, ovarian, head and neck, testicular, cervical, colorectal and relapsed lymphoma. The success of platinum drugs in treatment of various types of cancers has been challenged by problems of intrinsic and acquired resistance. Biochemical and genetical studies have confirmed that platinum resistance is multifactorial and includes changes in drug transport leading to decreased drug accumulation, increased drug inactivation or detoxification, changes in DNA repair and damage bypass and alterations in the apoptotic cell death pathways. Molecular studies have revealed that genetic factors and epigenetic mechanisms are linked to platinum resistance. Proteomimetics might prove to be clinically useful as new anticancer agents capable of overcoming apoptosis resistance. The study summarizes the current and future trends of novel molecular discoveries which will find new ways to combat platinum resistance and permit the designing of patient-specific pharmacological interventions to circumvent platinum resistance and increase the drug efficacy.
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