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Journal of Medical Sciences
  Year: 2013 | Volume: 13 | Issue: 1 | Page No.: 10-18
DOI: 10.3923/jms.2013.10.18
 
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Safety of Garlic (Allium Sativum) and Turmeric (Curcuma domestica) Extract in Comparison with Simvastatin on Improving Lipid Profile in Dyslipidemia Patients

Elin Yulinah Sukandar, Primal Sudjana, Joseph I. Sigit, Ni Putu E. Leliqia and Fetri Lestari

Abstract:
Dyslipidemia is the major cause of atherosclerosis. A number of drugs that inhibit cholesterol synthesis has indicated to control lipid profile. However, these lipid lowering drugs are not free of side effect. Therefore a substance that less toxic and yet effective would be beneficial. Here we compared the anticholesterol effect of combination of garlic and turmeric extract, a herbal product, with a standard lipid lowering drug, simvastatin. Thirty nine people were recruited and randomized into two groups, Garlic-Turmeric (G-T) group (n = 19) received three times two capsules of garlic-turmeric extract (2.4 g day-1) and simvastatin group (n = 20) received placebo and 5 mg simvastatin to blind the subjects from knowing what drugs they get, for 14 weeks. Garlic-turmeric extract could improve lipid profile comparable with simvastatin (p = 0.366). There were no adverse event related to garlic-turmeric administration, even there was improvement in liver function at the end of the study. In conclusion garlic-turmeric extract could improve lipid profile comparable to simvastatin with no significant adverse event.
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How to cite this article:

Elin Yulinah Sukandar, Primal Sudjana, Joseph I. Sigit, Ni Putu E. Leliqia and Fetri Lestari, 2013. Safety of Garlic (Allium Sativum) and Turmeric (Curcuma domestica) Extract in Comparison with Simvastatin on Improving Lipid Profile in Dyslipidemia Patients. Journal of Medical Sciences, 13: 10-18.

DOI: 10.3923/jms.2013.10.18

URL: https://scialert.net/abstract/?doi=jms.2013.10.18

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