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Journal of Medical Sciences

Year: 2010 | Volume: 10 | Issue: 3 | Page No.: 66-70
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Authors

B. Hajipour

M.H. Somi

F. Dibazar

N.A. Asl

A.M. Vatankhah

Keywords

Research Article

Anti-Oxidative Effect of Simvastatin in Liver and Lung Tissue after Hepatic Ischemia/Reperfusion in Rat

B. Hajipour, M.H. Somi, F. Dibazar, N.A. Asl and A.M. Vatankhah
In this research we studied simvastatin effect on liver and lung tissue anti-oxidant enzymes, 24 h after hepatic I/R. Male Wistar rats were randomly assigned into three groups of fifteen animals in each group. Group 1, the sham group, underwent laparotomy but did not experience I/R; group 2, the I/R group, underwent ischaemia for 30 min and were reperfused for 24 h; Group 3 underwent ischaemia and reperfusion like group 2 but also received 10 mg kg-1 simvastatin dissolved in water by oral gavage for three days before the operation. In animals subjected to hepatic I/R port triad clamped for 30 min following by 24 h reperfusion. Data showed that GPx and SOD levels in liver and lung tissue in I/R+simvastatin group were higher than I/R group significantly (p<0.05). MDA level in I/R group was significantly higher than I/R+simvastatin group in liver and lung tissue significantly (p<0.05). As simvastatin is a safe drug and result of our previous research and also this research show the efficacy of simvastatin pretreatment in decreasing liver and lung oxidative stress after hepatic I/R, so it may be useful in attenuating hepatic I/R injury and it may be effective for performing safer hepatic surgeries.
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