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Journal of Medical Sciences

Year: 2007 | Volume: 7 | Issue: 5 | Page No.: 884-887
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Authors

Sussan Soltani Mohammadi

Mohammad Hossein Ghafari

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Research Article

Comparing Propofol-ephedrine with Propofol-saline on Intubating Conditions after Priming by Atracurium

Sussan Soltani Mohammadi and Mohammad Hossein Ghafari
In this study we conducted a double blind, prospective, controlled trial comparing intubating conditions after induction with propofol-ephedrine or propofol-saline, after priming by atracurium. Seventy adult patients received 2 μg kg-1 fentanyl and priming dose of atracurium (0.05 mg kg-1) with preoxygeneation. After 2.5 min they were randomly assigned to receive either propofol 2.5 mg kg-1 and 140 μg kg-1 ephedrine or propofol 2.5 mg kg-1 and saline followed by atracurium 0.5 mg kg-1. Tracheal intubation was performed 30 seconds later. Jaw relaxation, vocal cord position and diaphragmatic response were used to assess intubating condition. There was no statistically significant difference in intubating condition between the two groups. Jaw relaxation and response to intubation was better in ephedrine group than saline group (p = 0.014 and p = 0.049, respectively). Vocal cord positions did not differ significantly between the two groups. There were not statistically significant differences in mean arterial pressure between and within two groups. There was statistically significant difference in heart rate between two groups (p = 0.01), but within subject test did not show significant difference in each group. The only complications were 2 cases of self-limiting sinus tachycardia of less than 130 beats min-1 in the ephedrine group. In conclusion ephedrine in dose of 140 μg kg-1 combining with propofol for intubation after priming by atracurium did not improve intubating condition and induced no clinically acceptable hemodynamic responses.
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