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Journal of Medical Sciences

Year: 2004 | Volume: 4 | Issue: 2 | Page No.: 102-109
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Authors

Mohammed A. Alsaif

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Research Article

Inhibition of Gastric Mucosal Damage by Boric Acid Pretreatment in Rats

Mohammed A. Alsaif
Boric acid was evaluated for its potential to protect the gastric mucosa against the injuries caused by 80% ethanol, 25% NaCl, 0.2 M NaOH and indomethacin in male Wistar rats. The effects caused by ethanol on gastric wall mucus, gastric levels of non-protein sulfhydryl groups, protein, nucleic acids and malondialdehyde and histopathological effects were also investigated. Boric acid pretreatment at oral doses of 60, 120 and 240 mg kg-1 body weight provided a dose-dependent protection against the ulcerogenic effects of different necrotising agents used. Treatment of rats with 1 ml of 80% ethanol (gavage) was found to cause depletion of stomach-wall mucus, to lower the concentrations of proteins, nucleic acids and non-protein sulfhydryl groups (NP-SH) in the stomach wall and to cause histopathological lesions, including necrosis, corrosion, congestion and hemorrhage. Boric acid treatment showed a dose-dependent protection against all these effects. In the same manner it affected malondialdehyde concentrations altered by ethanol pretreatment. Boric acid also offered protection against mucosal damage caused by indomethacin. Present findings show that boric acid possesses antiulcerogenic effects. Further studies are required to determine its role in the prophylaxis and or the treatment of gastric ulcer disease.
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