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Journal of Medical Sciences
  Year: 2002 | Volume: 2 | Issue: 4 | Page No.: 206-208
DOI: 10.3923/jms.2002.206.208
 
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Study of the Hypoglycemic Activity of Hedera helix L. in Alloxan-induced Diabetic Rabbits

Iqbal Zafar, Parvez Mohammad, Asadullah, Ismail Muhammad, Ahmad Bashir, Zakir Shahida and Gul Saima

Abstract:
The crude ethanolic extract of leaves of Hedera helix L. was orally administered to the alloxan-induced diabetic rabbits. Significant hypoglycemic activity (p < 0.05) was observed after 90 min. of the administration of the extract. The acute hypoglycemic activity was studied by the oral administration of the extract with a dose of 250 mg Kg-1 body weight daily for seven days. It significantly decreased the concentration of glucose in blood (P < 0.01) without any visible physical-physiological changes. The oral administration of ethanolic extract has a beneficial effect on the diabetic state by lowering the blood glucose level through extra-pancreatic actions rather than by stimulated insulin release.
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How to cite this article:

Iqbal Zafar, Parvez Mohammad, Asadullah, Ismail Muhammad, Ahmad Bashir, Zakir Shahida and Gul Saima, 2002. Study of the Hypoglycemic Activity of Hedera helix L. in Alloxan-induced Diabetic Rabbits. Journal of Medical Sciences, 2: 206-208.

DOI: 10.3923/jms.2002.206.208

URL: https://scialert.net/abstract/?doi=jms.2002.206.208

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