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Journal of Medical Sciences

Year: 2001 | Volume: 1 | Issue: 2 | Page No.: 81-86
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Authors

M.M. El- Mofty

A.E. Essawy

M.H. Shwaireb

A.M. Rizk

J.M. Sorour

S. El- Gendi

Keywords

Research Article

Comparative Study on the Inhibitory Effects of Topical Application and Feeding of Different Egyptian Garlic Extracts on Chemically Induced Skin Tumors

M.M. El- Mofty, A.E. Essawy, M.H. Shwaireb, A.M. Rizk, J.M. Sorour and S. El- Gendi
The effects of topical application and feeding of different garlic extracts on 7,12 dimethylbenz(a) anthracene (DMBA)-induced skin tumors in BALB/c mice were investigated. Topical application of ajoene or garlic oil highly prevented the appearance of skin tumors in experimental animals. Carcinomas had never developed , while papillomas had developed in 20 and 16.7% of animals treated with garlic oil and ajoene respectively, in comparison to 6.7% carcinomas and 93.3% papillomas incidence in carcinogenic control mice. Moreover, a significant decrease was observed in number of tumors per mouse and multiplicity. The time till the appearance of first tumor was extended. In contrary to the topical application, garlic extracts (ajoene, garlic oil and fresh minced garlic) had not exerted a significant inhibitory effect against skin tumorigenesis when they were supplemented in diet.
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How to cite this article

M.M. El- Mofty, A.E. Essawy, M.H. Shwaireb, A.M. Rizk, J.M. Sorour and S. El- Gendi, 2001. Comparative Study on the Inhibitory Effects of Topical Application and Feeding of Different Egyptian Garlic Extracts on Chemically Induced Skin Tumors. Journal of Medical Sciences, 1: 81-86.

DOI: 10.3923/jms.2001.81.86

URL: https://scialert.net/abstract/?doi=jms.2001.81.86

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