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Research Journal of Microbiology
  Year: 2011 | Volume: 6 | Issue: 4 | Page No.: 328-342
DOI: 10.17311/jm.2011.328.342
 
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Taificidin1 and Taificidin2, Two Anti-microbial Agents Isolated from the Fermentation Broth of Streptomyces roseodistaticus TA15 and Streptomyces lavendofoliae TA17

Abd Ul-Rahman Abd Allaa Al-Humiany

Abstract:
Isolation of antimicrobial agents from actinomycetes isolated from EL-Taif area, Kingdom of Saudi Arabia, two streptomyces isolates showed remarkable antimicrobial activity against tested organisms. The two isolates were previously identified according to the recommended keys as Streptomyces roseodistaticus TA15 and Streptomyces lavendofoliae TA17. The active metabolites of St. roseodistaticus TA15 and St. lavedofoliae TA17 were extracted by using different organic solvents, purified using both Thin Layer Chromatography (TLC) and column chromatography. The active compounds were concentrated and investigated for their physical characteristics and elemental, spectroscopic and biochemical analysis and their Minimum Inhibition Concentration (MIC) were determined. The cytopathic effect of the two antimicrobial agents on the vero cell virus, the neutralization test in monolayer cell cultures for antiviral test on coxasackie B4, hepatitis A and herpes simplex (cox B4, HAV and HSVI) viruses was also determined. Aim of this study is to identify the antimicrobial activity of actinomycetes extracts isolated from Saudi Arabia. We suggested the name "Taificidin 1" and "Taificidin 2" for the antimicrobial agent which extracted from St. roseodistaticus TA15 and from St. lavedofoliae TA17 as two active compounds isolated for first time from EL-Taif region, KSA.
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How to cite this article:

Abd Ul-Rahman Abd Allaa Al-Humiany , 2011. Taificidin1 and Taificidin2, Two Anti-microbial Agents Isolated from the Fermentation Broth of Streptomyces roseodistaticus TA15 and Streptomyces lavendofoliae TA17. Research Journal of Microbiology, 6: 328-342.

DOI: 10.17311/jm.2011.328.342

URL: https://scialert.net/abstract/?doi=jm.2011.328.342

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