The objective of this study was to evaluate the potential effect of sodium alginate from Sargassum crassifolium on glucose level and lipid profile in streptozotocin-induced diabetes rats. Sodium alginate extract of S. crassifolium 200, 400 and 600 mg kg1 was administered orally to streptozotocin-induced diabetes rats, once daily for 15 days. The result obtained were then compared with normal control (non-diabetic+normal saline 0.9% p.o), negative control (diabetes+CMC-Na 0.5% p.o) and positive control (diabetic+glibenclamide 5 mg kg1 p.o). The glucose level, lipid profile and body weight were measured on normal condition (baseline) on 0, 5th, 10th, 15th day and pancreatic histopathological study were done on 15th day. Sodium alginate extract of S. crassifolium had yield 23.82% db, viscosity of 521 cps and a water content of 16.18% db. Sodium alginate 600 mg kg1 significantly reduce level preprandial glucose, postprandial glucose and total cholesterol compared negative control and did not have significant difference with positive control. Levels of triglycerides and LDL-c throughout the treatment groups had significant differences with the negative control. Meanwhile, the levels of HDL-c throughout the treatment group did not have significant differences. Necrosis was found in all streptozotocin-induced rats. The higher alginate doses given, getting better lower the levels of glucose and total cholesterol. PDFFulltextXMLReferencesCitation
How to cite this article
Amir Husni, Dwi Purwanti and Ustadi, 2016. Blood Glucose Level and Lipid Profile of Streptozotocin-induced Diabetes Rats Treated with Sodium Alginate from Sargassum crassifolium. Journal of Biological Sciences, 16: 58-64.
Akinyele Kelechi Reply
It is very educative