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Journal of Biological Sciences

Year: 2014 | Volume: 14 | Issue: 8 | Page No.: 515-520
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Authors

Amir Husni

Renita Wijayanti

Ustadi

Keywords

Research Article

Inhibitory Activity of α-Amylase and α-Glucosidase by Padina pavonica Extracts

Amir Husni, Renita Wijayanti and Ustadi
The objective of this study was to determine the potential of polyphenols and phlorotannins extract from Padina pavonica in inhibiting α-amylase and α-glucosidase. Total phenolic content of P. pavonica was 17.63±0.25 μg GAE/mg extract and total phlorotannins content was 1.94±0.19 μg PGE/mg extract. The results showed that polyphenols (IC50 = 0.36±0.05 mg mL-1) and phlorotannins (IC50 = 0.25±0.02 mg mL-1) can inhibit α-amylase, but lower than acarbose (IC50 = 0.06±0.00 mg mL-1). Polyphenols (IC50 = 26.57±2.08 mg mL-1) and phlorotannins (IC50 = 34.40±5.93 mg mL-1) can also inhibit α-glucosidase but also lower than acarbose (IC50 = 1.74±0.25 mg mL-1). Both polyphenol and phlorotannin extracts from P. pavonica have higher inhibitory activity of α-amylase than α-glucosidase. There were high correlations between total phenolic and phlorotannin contents with inhibition activity of α-amylase and α-glucosidase.
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