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Journal of Biological Sciences

Year: 2010 | Volume: 10 | Issue: 7 | Page No.: 648-652
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Authors

Moazedi Ahmad Ali

Khombi Shooshtari Maryam

Parham Gholam Ali

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Research Article

Dose-dependent Effects of Iron Supplementation on Short-term and Long-term Memory in Adult Male Wistar Rats

Moazedi Ahmad Ali, Khombi Shooshtari Maryam and Parham Gholam Ali
The aim of the present study was to evaluate the effects of dose-dependent of iron supplementation on short-term and long-term memory in adult male rats in a shuttle box. Iron imbalance in the brain, including excess accumulation and deficiency are associated with neurological disease and dysfunction; yet, their origins are poorly understood. So, in this study were investigated the effects of iron on the behavior of adult wistar rats. Rats were treated with different doses of iron (0, 10, 20, 30, 50, 70, 100, 120, 150 mg kg-1) by gavage for 3 consecutive days and the effects of iron supplementation on passive avoidance memory were studied by shuttle box. The results showed that iron supplementation (20, 30 mg kg-1) significantly (p<0.01, p<0.001) improved short term memory and also, 30 mg kg-1 significantly (p<0.001) increased long term memory. But, 100 mg kg-1 impairment (p<0.05) short term memory. Thus, we can assume that the organism, particularly the adults, can compensate for a small dose of iron supplementation and there exists a mechanism that certainly protects the brain against iron overload until a certain point but cannot compensate for when the load exceeds this limit.
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