Research Article

**Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated with a Pyrethroid Insecticide**

The effect of the pyrethroid insecticide, fenvalerate, on the liver and kidney of toad (Bufo regularis) was studied. Feeding toads with a daily dose of fenvalerate (0.5 mg/kg body weight) for three weeks caused histopathological alterations in these organs. The normal structural organization of the hepatic acini was impaired, the hepatocytes showed cytoplasmic vacuolation, the blood vessels were congested and there was remarkable abundance of leucocytic infiltrations. In the kidney, the renal tubules were degenerated and the glomeruli were atrophied. Moreover, the transaminases enzymes GOT (glutamate-oxaloacetate transaminase) and GPT (glutamate-pyruvate transaminase) were elevated in the sera of treated animals. The magnitude of the changes was time-dependent being more prominent after the third week of treatment with fenvalerate.

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S. A. Sakr and S. M. Hanafy, 2002. Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated with a Pyrethroid Insecticide. Journal of Biological Sciences, 2: 208-211.

DOI: 10.3923/jbs.2002.208.211

URL: https://scialert.net/abstract/?doi=jbs.2002.208.211

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S. A. Sakr

S. M. Hanafy

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Research Article

**Histopathological Alterations in the Liver and Kidney of Toads (Bufo regularis) Intoxicated with a Pyrethroid Insecticide**

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