
	Journal of Applied Sciences
	Year: 2012 \| Volume: 12 \| Issue: 6 \| Page No.: 502-517 DOI: 10.3923/jas.2012.502.517

Novel Integrated Approach for the Strategic Delivery of Hydrophobic Drugs by the Use of Self Emulsifying Drug Delivery System

D.S. Rajput, Amit Alexander, Vishal Jain, T.K. Giri, D.K. Tripathi and Ajazuddin

Abstract: The oral delivery of hydrophobic drugs faces a major challenge because of the low aqueous solubility of such compounds. Approximately, 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system because of their low bioavailability. The availability of the drug for absorption can be enhanced by presentation of the drug as a solubilizer within a colloidal dispersion. Self-emulsifying Drug Delivery Systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. The principal characteristic of these systems is their ability to form fine oil-in-water (o/w) emulsions or microemulsions upon mild agitation following dilution by an aqueous phase through the gastrointestinal tract for lipophilic drugs, which display dissolution rate-limited absorption. SEDDS may be a promising strategy to improve the rate and extent of oral absorption. This article gives an overview of the recent advances in the study of SEDDS and improvement of pharmacokinetic parameters of bioactives through SEDDS.

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How to cite this article:

D.S. Rajput, Amit Alexander, Vishal Jain, T.K. Giri, D.K. Tripathi and Ajazuddin , 2012. Novel Integrated Approach for the Strategic Delivery of Hydrophobic Drugs by the Use of Self Emulsifying Drug Delivery System. Journal of Applied Sciences, 12: 502-517.

DOI: 10.3923/jas.2012.502.517

URL: https://scialert.net/abstract/?doi=jas.2012.502.517

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