Medical geography is the influence of environmental (natural and human) factors on biological system of human, plant and animals which is even recognized as an effective and basic factor in mortality. Geography is a hybrid science, a science which generates its components. If we take geography in association with the definition of human and environment and its reciprocal relation in such a way not to damage the environment, will it be possible to reveal that it is hybrid and that how wide is it? Yes, it has been extended as equal as the whole living environment (life layer) of human and living things as well as non-living things. While examining the various topics and concepts of environmental factors and medical sciences in the study of geographical factors including environmental and human factors, in present research it has been attempted to deal with the investigation on its effect in medicine as well as the conditions under which the human settlements were formed as a history. In this way, we will be able to have an insight into the settling of new settlements and/or to physically develop other settlements including urban and rural environments and even to consider this case in modifying of the existing spaces. Medical geography, in addition to involving in various environmental factors, considers the diffusion of different diseases in various geographical locations and continental conditions and also, this science acts to timely prevent such situations as they are obstacles in the process of stable development.