Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Applied Sciences
  Year: 2009 | Volume: 9 | Issue: 12 | Page No.: 2287-2293
DOI: 10.3923/jas.2009.2287.2293
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Surfactant-Free Nanospheres of Methoxy Poly (Ethylene Glycol)-b-Poly (ε-Caprolactone) for Controlled Release of Ibuprofen
Yodthong Baimark

Abstract: Aims of this study were to synthesize methoxy poly (ethylene glycol)-b-poly (ε-caprolactone) diblock copolymers (MPEG-b-PCL) and to prepare their surfactant-free nanospheres by modified-spontaneous emulsification solvent diffusion method for controlled release delivery of hydrophobic drug. Ibuprofen was used as a poorly-water soluble model drug. Influences of PCL block length and drug loading content on nanosphere characteristics and drug release behaviors were evaluated. The prepared nanospheres with and without drug loading were found of spherical shape and smooth surface with size less than 150 nm. FTIR spectroscopy and differential scanning calorimetry studies showed the interactions between ibuprofen and MPEG-b-PCL had occurred, suggesting the well distribution of ibuprofen into nanosphere matrices. An increase in the PCL block length led to a decrease in drug encapsulation efficiency. The drug release profiles were biphasic with a fast burst release followed by a slow one. The drug release rates from the MPEG-b-PCL nanospheres strongly depended on the PCL block length and the drug loading content.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Nanotechnology: A Tool to Enhance Therapeutic Values of Natural Plant Products
  •    Preparation of Surfactant-free Linear and Star-shaped Poly(L-lactide)-b-methoxy Polyethylene Glycol Nanoparticles for Drug Delivery
  •    Targeted Drug Nanoparticles: An Emphasis on Self-assembled Polymeric System
How to cite this article:

Yodthong Baimark , 2009. Surfactant-Free Nanospheres of Methoxy Poly (Ethylene Glycol)-b-Poly (ε-Caprolactone) for Controlled Release of Ibuprofen. Journal of Applied Sciences, 9: 2287-2293.

DOI: 10.3923/jas.2009.2287.2293

URL: https://scialert.net/abstract/?doi=jas.2009.2287.2293
COMMENT ON THIS PAPER
 
 
 

 
  Bullet Navigation
 
  Page Icon Online First
  Page Icon Current Issue
  Page Icon Previous Issues
  Page Icon Editorial Board
  Page Icon Submit a Manuscript
  Page Icon Guide to Authors
  Page Icon Subscribe to E-alerts

  Bullet Indexed In
 
  Page Icon AGRIS
  Page Icon ASCI-Database
  Page Icon Asian Digital Library
  Page Icon Chemical Abstract Services
  Page Icon Google Scholar

Science Alert
Curve Bottom