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Journal of Applied Sciences
  Year: 2008 | Volume: 8 | Issue: 7 | Page No.: 1235-1241
DOI: 10.3923/jas.2008.1235.1241
 
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Type 2 Diabetes in Han Chinese in Hubei
Mustafa Abdo Saif Dehwah, Zhang Shuang , Wang Yan , Peng Chan and Qing-Yang Huang

Abstract: The aim of this study was to investigate the association between Pro12Ala polymorphism in the PPARγ2 gene and type 2 diabetes mellitus in Han Chinese in Hubei. Peroxisome proliferator activated receptorγ2 (PPARγ2) is a nuclear receptor plays a key role in regulation of adipocyte differentiation, lipid metabolism, insulin sensitivity and the development of type 2 diabetes mellitus (T2DM). There are various studies have provided evidence for the association between common Pro12Ala polymorphism in the PPARγ2 gene and type 2 diabetes mellitus, but the results are controversial and depend on ethnicity. So we conducted a case-control association study among 330 T2DM patients and 212 controls with family-based and random case-control designs. The genotypes of the PPARγ2 Pro12Ala polymorphism were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFL) method. The result indicated that the Pro12 allele was associated with type 2 diabetes in this study population.
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How to cite this article:

Mustafa Abdo Saif Dehwah, Zhang Shuang , Wang Yan , Peng Chan and Qing-Yang Huang , 2008. Type 2 Diabetes in Han Chinese in Hubei. Journal of Applied Sciences, 8: 1235-1241.

DOI: 10.3923/jas.2008.1235.1241

URL: https://scialert.net/abstract/?doi=jas.2008.1235.1241
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