Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Zoological Research
  Year: 2012 | Volume: 8 | Issue: 2 | Page No.: 98-105
DOI: 10.3923/ijzr.2012.98.105
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Physiological Study of Lipoprotein Lipase Gene Pvu II Polymorphism in Cases of Obesity in Egypt
Ahmed Hendawy, Mansour Hasan, Rizk Elbaz, Ghada El-Kannishy, Saad Elshaer and Ahmed Settin

Abstract:
Genetic predisposition has been implicated in obesity. Lipoprotein lipase (LPL) gene, the main lipase of chylomicrons and Low Density Lipoproteins (LDL), has a fundamental role in the transport and metabolism of plasma cholesterol. The present study was undertaken to test for the association of the LPL gene Pvu II polymorphism with obesity with or without hypertension and diabetes and dyslipidemia among affected Egyptian cases. This study has included 120 subjects affected with obesity; 57 of them were affected with metabolic syndrome (with diabetes, dyslipidemia and hypertension) while the other 63 cases were not complicated and were termed “simple obesity”. These cases were compared to 83 healthy non-obese controls. Body Mass Index (BMI), Waist Hip Ration (WHR) and serum lipid levels were measured. The LPL gene polymorphic alleles were determined by PCR-RFLP that includes polymerase chain reaction for gene amplification followed by digestion with Pvu II enzyme and analysis according to the size of digested amplified DNA. Obesity cases had a significantly higher frequency of the homozygous mutated LPL Pvu II (+/+) genotype and also of the (+) allele particularly among metabolic syndrome cases compared to controls. Cases with the (+/+) homozygous genotype showed significantly higher frequency of diabetes, lower frequency of positive family history and lower values for waist hip ratio than those with the (+/-) and (-/-) genotypes. These cases have showed also higher levels of total cholesterol and LDL-C, yet not reaching statistical significance. This study showed a significant association between the LPL Pvu II gene polymorphism and obesity among Egyptian cases particularly when complicated with the metabolic syndrome.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Prevalence of and Factors Associated with Overweight and Obesity among Jordan University Students
How to cite this article:

Ahmed Hendawy, Mansour Hasan, Rizk Elbaz, Ghada El-Kannishy, Saad Elshaer and Ahmed Settin, 2012. Physiological Study of Lipoprotein Lipase Gene Pvu II Polymorphism in Cases of Obesity in Egypt. International Journal of Zoological Research, 8: 98-105.

DOI: 10.3923/ijzr.2012.98.105

URL: https://scialert.net/abstract/?doi=ijzr.2012.98.105

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom