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International Journal of Virology

Year: 2011 | Volume: 7 | Issue: 2 | Page No.: 53-63
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Authors

R. Shrivastava

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Research Article

A New Therapeutic Approach to Neutralize Throat Surface Proteases and Virus Glycoproteins Simultaneously for the Treatment of Influenza Virus Infection

R. Shrivastava
Influenza virus capsid contains surface glycoproteins and virus takes the help of topically available proteases to enter into the host cells. As the proteases and the virus capsid glycoproteins are proteins in nature, the aim of this study was to test some tannin rich plant extracts, either alone or in association, so as to neutralize proteases as well as virus glycoproteins to stop further infection. MDCK cells were infected with influenza virus in the presence or absence of MMP (Matrix Metalloproteinases) proteases and various plant extracts using cytopathic virus concentrations to evaluate the role of MMP proteases and tannin rich plant extracts on virus growth in vitro. Results indicate that plant tannins can bind to specific viral proteins and proteases but requires highly specific associations to inhibit total virus activity. These results prove that specific proteases are involved in influenza virus infection and simultaneous neutralization of virus glycoproteins and proteases constitute the most promising approach to treat influenza infection.
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