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International Journal of Pharmacology

Year: 2019 | Volume: 15 | Issue: 1 | Page No.: 56-65
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Authors

Aslam Khan

Najeeb-ur-Rehman

Najeeb-ur-Rehman

Anwarul-Hassan Gilani

Anwarul-Hassan Gilani

Zunirah Ahmed

Shaza Al-Massarani

Ali. El-Gamal

Mohamed Farag

Keywords

Background and Objectives: Albizia lebbeck is famous plant for its medicinal use in hyperactive gut and airways disorders. The objective of this study was therefore to provide a scientific rationale for the medicinal utility of Albezia lebbeck in diarrhea, gut spasm and bronchospasm, with the possible mode of action explored. Materials and Methods: The hydro-alcoholic extract of the pericarp of Albezia lebbeck (Al.Pericarp) was tested using in-vivo and in-vitro assays. Results: Albezia Pericarp, at 100 and 300 mg kg–1 showed 40 and 80% protection of castor oil-induced diarrhea in mice, whereas loperamide (10 mg kg–1) showed complete protection. In isolated rabbit jejunum, Albezia. Pericarp completely inhibited spontaneous, carbachol (CCh; 1 μM) and low K+ (25 mM)-induced contractions but had only a weak effect against high K+ (80 mM). When tested for bronchodilatory activity in anesthetized rats, Albezia. Pericarp (3-30 mg kg–1) inhibited the CCh-induced bronchospasm in a dose-dependent manner, similar to aminophylline. In isolated guinea-pig tracheal preparations, Al.Pericarp selectively inhibited contractions induced by CCh and low K+. The inhibitory effect of Al.Pericarp against low K+ was reversed in the presence of tetraethylammonium (TEA), a non-specific blocker of K+-channels, whereas no significant inhibition was observed in the presence of glibenclamide (Gb) or 4-aminopyridine (4-AP), which are ATP-dependent and voltage-dependent K+ channel blockers, respectively. The plant extract (0.03 and 0.01 mg mL–1) also potentiated isoprenaline-inhibitory concentration-response curves (CRCs) by a shift to the left, in both jejunum and trachea, showing phosphodiesterase inhibition, similar to papaverine. Conclusion: These results indicated that the crude extract of Albizia lebbeck Pericarp possesses anti diarrheal, antispasmodic and bronchodilatory activities, mediated possibly through dual pathways, namely activation of a non-specific type of K+-channels and inhibition of phosphodiesterase enzyme. Thus, this study offered a sound basis for Albizia lebbeck to be developed for hyperactive gut and airways disorders.
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How to cite this article

Aslam Khan, Najeeb-ur-Rehman, Anwarul-Hassan Gilani, Zunirah Ahmed, Shaza Al-Massarani, Ali. El-Gamal and Mohamed Farag, 2019. Possible Mechanism(s) Underlying the Antidiarrheal, Antispasmodic and Bronchodilatory Activities of the Pericarp of Albizia lebbeck. International Journal of Pharmacology, 15: 56-65.

DOI: 10.3923/ijp.2019.56.65

URL: https://scialert.net/abstract/?doi=ijp.2019.56.65

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