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Protective Effect of Ginsenoside Rg1 Against Ethanol-Induced Male Infertility in Sprague-Dawley Rats |
Zhenzhen Jin,
Min Zhang,
Aijun Yang,
Yafei Shi,
Huanfu Niu,
Qin Wang,
Chunna Yu,
Zefeng Wei and Xuenan Wang  |
Abstract:
Background and Objective: Ginsenoside Rg1 (GRg1) is the most abundant and active steroid saponin of Panax notoginseng with several pharmaceutical properties. The present study was undertaken to evaluate the effect of ginsenoside Rg1 (GRg1) on ethanol-induced male infertility in rat model. Materials and Methods: Thirty-two male rats were divided into four groups. One group (control) received saline (2 mL/day), while another group was given ethanol (EtOH, 4 g kg–1 b.wt./day). One treatment group received 20 mg GR1 kg–1 b.wt./day, while another treatment group was given 40 mg GR1 kg–1 b.wt./day. Both treatment groups were also given 4 g EtOH kg–1 b.wt./day. All treatment were given orally for 28 days. The significant differences between the groups were determined using one-way ANOVA and data were analyzed using SPSS software followed by Tukey’s test. Results: The weights of epididymis, testis and seminal vesicles, as well as testicular sperm count, viability, motility and serum testosterone levels were significantly elevated (p<0.01) by exposure to GRg1 at each of the two doses (20 and 40 mg kg–1 b.wt./day), when compared to the EtOH-treated groups. The two doses of GRg1 also led to significant (p<0.01) increases in the activities of testicular antioxidant enzymes (SOD, CAT) and the steroidogenic enzymes 3β hydroxy steroid dehydrogenase (3β HSD) and 17β hydroxy steroid dehydrogenase (17β HSD), as well as lower levels of MDA. Histomorphological lesions such as thickening of seminiferous tubules and disintegration of leydig and sertoli cells were ameliorated by both doses of GRg1. However, 40 mg kg–1 GRg1 showed better anti-infertility effect. Conclusion: Co-administration of ethanol and 40 mg kg–1 GRg1 to rats produced anti-infertility effects by suppressing alcohol-induced sperm oxidative stress and testicular toxicity.
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How to cite this article:
Zhenzhen Jin, Min Zhang, Aijun Yang, Yafei Shi, Huanfu Niu, Qin Wang, Chunna Yu, Zefeng Wei and Xuenan Wang, 2018. Protective Effect of Ginsenoside Rg1 Against Ethanol-Induced Male Infertility in Sprague-Dawley Rats. International Journal of Pharmacology, 14: 513-521.
DOI: 10.3923/ijp.2018.513.521
URL: https://scialert.net/abstract/?doi=ijp.2018.513.521
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