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International Journal of Pharmacology

Year: 2016 | Volume: 12 | Issue: 5 | Page No.: 514-522
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Authors

Kumeshini Sukalingam

Kamsiah Jaarin

Qodriyah Haji Mohd Saad

Qodriyah Haji Mohd Saad

Suhaila Mohamed

Suhaila Mohamed

Faizah Othman

Keywords

Background and Objective: Oxidative stress is connected with the pathogenesis of cardiovascular diseases. A series of deep-fat frying in dietary cooking oil produce more amount of reactive oxygen species. In this study, repeatedly heated palm oil and ADD-X were studied for its effect on the Blood Pressure (BP), lipid peroxidation and antioxidant parameters. Methodology: Thirty female Sprague-Dawley rats were divided into 5 groups with 6 rats each. All groups of the animals were ovariectomized after anesthetized. Group 1 was fed 2% cholesterol chow (Chol-C), groups 2 and 4, respectively fed 2% cholesterol chow along with 5 and 10 times heated palm oil (5 HPO and 10 HPO). Groups 3 and 5 were respectively given 2% cholesterol chow with 5 HPO and 10 HPO along with ADD-X. Duration of the feeding was 6 months. Systolic, diastolic and mean BP were monitored 4 weeks intervals using a non-invasive method. At the end of the study, blood was collected for oxidative stress and antioxidant parameters. Results: The BP was elevated significantly (p<0.05) in 10 HPO and 5 HPO groups, respectively, where the 10 HPO group viewing higher values. The Increased in BP was significantly lower in ADD-X treated groups. The level of thiobarbituric acid reactive substances (TBARS) was significantly increased in 5 HPO and 10 HPO treated animals and decrease antioxidant parameters compared to Chol-C animals. Consumption of ADD-X reduces TBARS and increase antioxidant enzymes. Conclusion: Repeatedly heated palm oil increases BP, lipid peroxidation and decrease antioxidant enzymes. Supplementation of ADD-X reversed the BP and reduce oxidative stress biomarkers in the post menopausal rat models.
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How to cite this article

Kumeshini Sukalingam, Kamsiah Jaarin, Qodriyah Haji Mohd Saad, Suhaila Mohamed and Faizah Othman, 2016. Consumption of ADD-X and Repeatedly Heated Palm Oil on the Blood Pressure and Oxidative Stress Markers in Ovarectmized Rats. International Journal of Pharmacology, 12: 514-522.

DOI: 10.3923/ijp.2016.514.522

URL: https://scialert.net/abstract/?doi=ijp.2016.514.522

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