|
|
| |
In vitro Antibacterial and in vivo Brine Shrimp Lethal Active Compounds Isolated from the Leaves of Saurauia roxburghii |
|
Yunus Ahmed,
Zahira Yaakob,
Parul Akhtar,
Mahbubur Rahman and Faridul Islam |
Abstract:
Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mL–1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.
|
|
|
PDF
Fulltext
XML
References
Citation
Report Citation
|
|
|
|
| RELATED ARTICLES: |
|
|
|
|
How to cite this article:
Yunus Ahmed, Zahira Yaakob, Parul Akhtar, Mahbubur Rahman and Faridul Islam, 2015. In vitro Antibacterial and in vivo Brine Shrimp Lethal Active Compounds Isolated from the Leaves of Saurauia roxburghii. International Journal of Pharmacology, 11: 821-827.
DOI: 10.3923/ijp.2015.821.827
URL: https://scialert.net/abstract/?doi=ijp.2015.821.827
|
|
|
|
|
| COMMENT ON THIS PAPER |
|
|
|
|
| |
 |
Navigation |
| |
|
|
| |
|
Indexed In |
| |
|
|
